Sleep disruption and duration are associated with variants in genes involved in energy homeostasis in adults with HIV/AIDS

To determine whether selected genes and plasma markers involved in energy homeostasis are associated with sleep disruption or duration adults HIV/AIDS. A sample of 289 HIV/AIDS wore a wrist actigraph for 72 h to estimate total time (TST) wake after onset (WASO). Twenty-three single nucleotide polymorphisms (SNP) spanning 5 (adiponectin [ADIPOQ], ghrelin [GHRL], leptin [LEP], peroxisome proliferator-activated receptor-alpha [PPARA], -gamma [PPARG]) were genotyped using custom array. Plasma (adiponectin, ghrelin, leptin) measured by commercial multiplex assay. After adjusting demographic clinical characteristics (race/ethnicity, gender, CD4 cell count, waist circumference, medications), both WASO TST SNPs ADIPOQ (rs182052), LEP (rs10244329, rs3828942), PPARA (rs135551, rs4253655), PPARG (rs709151). Additional (rs1501299, rs3821799, rs6773957) (rs2241766). was also GHRL (rs26802), (rs11760956), (rs135547, rs8138102, rs4253776), (rs12490265, rs796313). Many covariate-adjusted associations significant interaction HIV (viral load, years since diagnosis). Among markers, higher adiponectin less WASO, glucose levels shorter TST, longer TST. Replication all five three objective measures. disease influenced many the associations. Findings strengthen evidence between genetics poor sleep, provide direction pharmacological intervention research.